There are a few ways to help with the nausea. 1) Opioid selection. Not all opioids are the same and some are more likely to cause nausea. Why did you specifically mention Percocet and Darvocet (you can't really take both at the same time)? The nausea from opioid medications is similar to nausea in motion sickness. For non-pharmaceutical options I would recommend candied ginger, as well as lying still and trying to sleep. The nausea from opioid medications usually decreases in a few days, which may be helpful if you plan to take the medication for a while. How to combat nausea from percocet? II have some generic percocet left over from a dental procedure and I take one occasionally when I am in intense pain, abdominal cramps and such. They make me so nauseous so I started only taking half, still with intense nausea and vomiting. Oxycodone comes in a variety of preparations, including capsules, extended release tablets and liquid solution. Take the medication in accordance with your doctor's recommendation and the label instructions. Hi Lexi, I have to use medications - but my nausea relates mostly to gastroparesis - delayed stomach emptying - rather than a direct effect of the opioids. If your brother tells the doctor that the percocet is not lasting the full four hours maybe he will either switch him over or tell him to take the percocet every 3 hours instead, after my first surgery i was taking percocet 2 tabs every 3 hours for months. Nausea, alone or accompanied by vomiting, can be miserable and is especially troublesome if you are in pain and need to take pain medication. Pain killers, especially those that contain opiates like codeine and oxycodone, can cause nausea. You can also use it only sparingly and when needed. If your pain is at a level that you need it frequently, you might ask your primary care physician for an anti-nausea medication such as Reglan (metoclopramide) or zofran. Percocet is a combination of oxycodone and acetaminophen, two pain relievers that act on separate pain receptors in the brain. The combination is designed to relieve moderate to severe pain after an injury or surgery, and it is not intended to be used for chronic pain conditions unless there is breakthrough pain. II have some generic percocet left over from a dental procedure and I take one occasionally when I am in intense pain, abdominal cramps and such. They make me so nauseous so I started only taking half, still with intense nausea and vomiting. I've read that there is medication you can take for the nausea as well. Is it over the counter?.